Ca2+ signaling through ryanodine receptor 1 enhances maturation and activation of human dendritic cells.
نویسندگان
چکیده
Increases in intracellular Ca2+ concentration accompany many physiological events, including maturation of dendritic cells, professional antigen-presenting cells characterized by their ability to migrate to secondary lymphoid organs where they initiate primary immune responses. The mechanism and molecules involved in the early steps of Ca2+ release in dendritic cells have not yet been defined. Here we show that the concomitant activation of ryanodine receptor-induced Ca2+ release together with the activation of Toll-like receptors by suboptimal concentrations of microbial stimuli provide synergistic signals, resulting in dendritic cell maturation and stimulation of T cell functions. Furthermore, our results show that the initial intracellular signaling cascade activated by ryanodine receptors is different from that induced by activation of Toll-like receptors. We propose that under physiological conditions, especially when low suboptimal amounts of Toll-like receptor ligands are present, ryanodine receptor-mediated events cooperate in bringing about dendritic cell maturation.
منابع مشابه
Erratum Ca2+ signaling through ryanodine receptor 1 enhances maturation and activation of human dendritic cells
Laura Bracci1,*,‡, Mirko Vukcevic2,*, Giulio Spagnoli1, Sylvie Ducreux2, Francesco Zorzato3 and Susan Treves2,3,§ 1Institute of Surgical Research and 2Departments of Anesthesia and Research, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland 3Department of Experimental and Diagnostic Medicine, General Pathology Section, University of Ferrara, 44100 Ferrara, Italy *These authors...
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ورودعنوان ژورنال:
- Journal of cell science
دوره 120 Pt 13 شماره
صفحات -
تاریخ انتشار 2007